Robert Dale Rowell already had a killing on his ledger when he was sent to death row for shooting three people at a Houston crack house, killing two of them.
The 50-year-old death row inmate faces execution just after 6 p.m. Tuesday for the bloody 1993 rampage that left 38-year-old Raymond Mata dead.
Fifty-two-year-old Irvin Wright also was killed in the shootings.
Mata's wife, Angie Perez, was left paralyzed.
The U.S. Supreme Court refused last month to review Rowell's case.
Rowell would be the 18th Texas prisoner executed this year and the first of two on consecutive nights this week.
Condemned inmate Shannon Thomas is to follow him to the death chamber Wednesday night for a Christmas Eve 1993 triple slaying in Baytown.
One other execution is scheduled in Texas for December.
If carried out, Texas will have executed 20 inmates this year, three fewer than a year ago and the fewest for a year in Texas since 17 in 2001.
A record 40 were executed in 2000.